Table 2 MIC distribution of BDQ resistant isolates against SM, EMB, KM and OFX
Drug resistance profile | No. of strains | No. of strains with different MIC (μg/ml) | No. (%) of BDQ resistant strains | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
≤ 0.008 | 0.016 | 0.031 | 0.063 | 0.125 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | |||
All isolates | 205 | 8 | 28 | 77 | 50 | 26 | 7 | 6 | 3 | 0 | 0 | 0 | 9 (4.4) |
Fully susceptible isolates | 31 | 2 | 6 | 13 | 7 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0(0) |
Resistant to one drug | 56 | 4 | 5 | 22 | 15 | 7 | 2 | 1 | 0 | 0 | 0 | 0 | 1(1.8) |
Resistant to two drugs | 76 | 1 | 11 | 30 | 17 | 11 | 3 | 3 | 0 | 0 | 0 | 0 | 3 (3.9) |
Resistant to three drugs | 35 | 1 | 4 | 11 | 9 | 5 | 1 | 2 | 2 | 0 | 0 | 0 | 4(11.4) |
Resistant to four drugs | 7 | 0 | 2 | 1 | 2 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1(14.4) |
Resistant to SM | 148 | 3 | 18 | 57 | 35 | 23 | 5 | 6 | 1 | 0 | 0 | 0 | 7(4.7) |
Resistant to EMB | 77 | 2 | 9 | 28 | 17 | 12 | 3 | 4 | 1 | 0 | 0 | 0 | 5(6.5) |
Resistant to OFX | 86 | 2 | 13 | 27 | 23 | 11 | 2 | 6 | 2 | 0 | 0 | 0 | 8(9.3) |
Resistant to KM | 30 | 2 | 7 | 7 | 9 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 1(3.3) |
Resistant to SM and (or) EMB | 82 | 4 | 8 | 35 | 18 | 13 | 3 | 1 | 0 | 0 | 0 | 0 | 1(1.2) |
Resistant to KM and (or) OFX | 13 | 1 | 3 | 3 | 4 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1(7.7) |
Resistant to any first and second line drugs | 79 | 1 | 11 | 26 | 21 | 10 | 3 | 5 | 2 | 0 | 0 | 0 | 7(8.9) |